Protein chainmail: catenanted protein in viral capsids. Circular dimer and catenate forms of mitochondrial DNA in human leukaemic leucocytes. Catenated circular DNA molecules in HeLa cell mitochondria. The present study thus details a simple approach to the creation and control of complex molecular architectures under reaction conditions that mimic biological milieux. In addition, the labile hydrazone linkages of the individual catenane components may be ‘locked’ by increasing the pH of the solution, yielding a relatively kinetically stable molecule. The quantitative synthesis process and the mechanically interlocked structure of the resulting catenane were established by NMR spectroscopy, mass spectrometry, X-ray crystallography and HPLC studies. Here, we present the preparation of a three-dimensional catenane through a self-assembly process that relies on the formation of dynamic hydrazone linkages in an acidic aqueous medium.
However, the preparation of purely covalent molecular architectures in aqueous media has remained a challenging task. “Lynch’s work is overflowing with wit… Lynch cleverly and dramatically subverts expectations, delivering a fast-moving and very fun zombie blood-fest that challenges ideas about femininity and teenage love.Self-assembly by means of coordinative bond formation has opened up opportunities for the high-yield synthesis of molecules with complex topologies. “Stella is no Bella… Not your run-of-the-mill zombie book, this title has heart.” – School Library Journal The third and final book in the trilogy, Biology, is currently being written. The sequel, History, is far too long but her fans don’t seem to mind that at all. Chemistry was a finalist in the Wishing Shelf Book Awards and winner of a 2017 IndieReader Discovery Award. She ended up with a zombie rom-com with a surprising amount of heart. She wrote her first novel, Chemistry, because she wanted to write a book which was “the exact opposite of Twilight,” featuring an assertive heroine and a respectful love interest. Her entire life now makes a lot more sense.
Lynch is a socially awkward introvert who recently realized that she is actually autistic.
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